Peyman Golshani (Med School, UCLA), a key member in our HFSP collaboration is visiting Budapest and as part of the visit he will give a talk at KOKI (Institute for Experimental Medicine) on Monday, 9 September
Title: New tools for discovering neural dynamics underlying neurological disease
Venue: KOKI seminar room
Time: 1100 AM, Monday, 9 September
Title: New tools for discovering neural dynamics underlying neurological disease.
Abstract: We have developed open-source tools to track activity patterns in large numbers of neurons in freely behaving animals using miniaturized microscopy. Our open source miniaturized microscopes have been released to the neuroscience community and over 500 laboratories have built and are using the scopes. As a part of the BRAIN initiative we have developed several new versions of the microscope. Our version 4 miniaturized microscope weighs nearly half as much and almost doubles of the field of view of the current microscope. We have designed new versions of this scope with a 3 X 3 mm field of view for non-human primates. We have also developed a wire-free version that logs the data onto a microSD card on the head of the animal. Lastly we have developed a version of the microscope that amplifies and digitizes 32 channel electrophysiological recordings at the same time as miniaturized microscopy data through a single co-axial wire. We have used our miniaturized microscope in a model of temporal lobe epilepsy and have found dramatically reduced stability and precision of place cells in these animals, suggesting a substrate for the degraded cognitive abilities of the animals and humans with temporal lobe epilepsy.